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This study in NEJM concludes: The neuropathic postural tachycardia syndrome results from partial sympathetic denervation, especially in the legs.

I can vouch for this, personally. It made my lifelong POTS and NCS/NMH very, very severe. Download the full PDF here:

http://www.nejm.org/doi/pdf/10.1056/NEJM200010053431404